Apart from distinct fragmentation of natural habitats caused by agricultural activity, forests and other ecosystems are additionally fragmented by a dense roadway infrastructure and other forms of exploitation. Roe deer and wild boar are representatives of tall game, while the predominant small mammals are hares, fox, martens, weasels, polecats and badgers. Herpetofauna is very well developed, especially in the rocky terrain parts of the Ovčar-Kablar gorge. The gorge is also considered an ornithological (bird watching) park.
Over 60% of the area (433 sq km) is used for various agricultural activity, so that the flora and fauna are conditioned by the cultivated plants and animals, 158 sq km are free land which is mostly continental deciduous forests with meadows with good grass coverage. The predominant forest trees are oak, hornbeam, beech, European ash, aspen, maple, linden, poplar, etc. Conifers were introduced to the slopes of the Ovčar, Kablar and Jeljen mountains by artificial forestation. There is also some marshland vegetation by the banks of the Zapadna Morava River, and as of sooner, in ponds formed around the lakes in the Ovčar-Kablar gorge. There are interesting parts of submediterranian – Balkan relic forests on the Ovčar and Kablar mountains.